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Ebola Death Rates Vary Widely by Age Group

LIVE SCIENCE       by

Young children who are infected with Ebola may be more likely to die from the virus than older children or adults who are infected, according to a new study.

 In the study, researchers examined Ebola cases in children younger than 16 during the current outbreak in Guinea, Liberia and Sierra Leone, and compared them with adult cases. They found that the outbreak's death rate has been higher among younger children than among older children and adults.

The disease has killed about 90 percent of infected children under age 1, and about 80 percent of kids ages 1 to 4 who have been infected. Older children who have been infected with Ebola may have a much better chance of surviving....

"The very youngest of children — neonates  —appear to have the worst outcomes from Ebola," study co-author Dr. Robert Fowler, an associate professor of critical-care medicine at the University of Toronto, said in a statement. (Neonates, or newborns, are babies younger than 1 month.)

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Fighting cancer and Ebola with nanoparticles

CNN  by

In medicine, finding a substance that attacks cancerous tumors without destroying the healthy tissue around it has long been the Holy Grail.

From targeted remedies such as monoclonal antibodies to surgery, cancer has still managed to elude a treatment that discretely and separately attacks it alone.

Nanotechnologies, however - the manipulation of matter at a molecular and even atomic scale to penetrate living cells -- are holding out the promise of opening a new front against deadly conditions from cancer to Ebola.

According to Dr Thomas Webster, the chair of chemical engineering at Northeastern University in Boston, research into medical nanotechnology is gaining pace and the medical establishment is starting to sit up and pay attention.

Read complete story.

http://www.cnn.com/2015/03/25/tech/webster-nanoparticles-cancer-mci/

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Fighting cancer and Ebola with nanoparticles

CNN  by

In medicine, finding a substance that attacks cancerous tumors without destroying the healthy tissue around it has long been the Holy Grail.

From targeted remedies such as monoclonal antibodies to surgery, cancer has still managed to elude a treatment that discretely and separately attacks it alone.

Nanotechnologies, however - the manipulation of matter at a molecular and even atomic scale to penetrate living cells -- are holding out the promise of opening a new front against deadly conditions from cancer to Ebola.

According to Dr Thomas Webster, the chair of chemical engineering at Northeastern University in Boston, research into medical nanotechnology is gaining pace and the medical establishment is starting to sit up and pay attention.

Read complete story.

http://www.cnn.com/2015/03/25/tech/webster-nanoparticles-cancer-mci/

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Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons learned from, the Ebola outbreake

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

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WHO Ebola Situation Report - 25 March 2015

WHO  WEEKLY SITUATION REPORT                                         March 25, 2015

Summary 

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Exposure Concerns Grow in Liberia After Diagnosis of First Ebola Case in Weeks

NEW YORK TIMES  by Sheri Fink                                                            March  25, 2015

Worries have widened in recent days over the number of people in Liberia who may have been exposed to the country’s first Ebola case in more than two weeks, a street vendor who lived in a one-bathroom house shared with 52 others in a Monrovia suburb and who had sold food at a school where more than 1,900 students are enrolled.

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New Ebola trial vaccine 'safe': researchers

AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

 But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

Read complete story.
http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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A Chemical Within a Traditional Chinese Medicine Has been Found to Be Effective Against Ebola

      

Health workers in protective clothing speak with new arrivals in the outpatient waiting room of Redemption Hospital, formerly an Ebola holding centre, in Liberia.  John Moore/Getty Images

CLICK HERE - SCIENCE - REPORT - Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

businessinsider.com.au - by Chris Pash - February 27, 2015

A chemical found in the Chinese herb known as Han Fang ji switches off the channels which the Ebola virus uses to enter and infect cells, according to research by US and German scientists.

The scientists found that using a small dose of the chemical tetrandrine, but not the herb itself, stopped the virus from replicating and protected mice from the disease without obvious side effects.

The discovery of the promising drug therapy against Ebola is announced in the journal Science.

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Sex the Hidden Culprit: A New Dimension in Ebola Infections in Liberia

africansuntimes.com - by Mardia Stone, M.D. - March 23, 2015

On March 20th, a newly confirmed Ebola case was reported [in Liberia] . . . This time, sexual contact is presumed to be the hidden culprit in this new Ebola virus transmission, according to a statement from the Ministry of Information and case reports from the National Ebola Response Team.

The story goes like this. . . .

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(ALSO SEE RELATED INFORMATION HERE)

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