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Read more about Low-cost portable device that can detect Ebola
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Ebola crisis provides framework for responding to outbreaks like Zika virus

Fri, 2016-03-18 11:28 — davidmc

As world leaders grapple with containing the Zika virus, the Ebola epidemic in West Africa provides valuable lessons for how to respond to other infectious disease epidemics, according to a policy report published by researchers at Princeton University and the Wellcome Trust.

Rebuilding local health care infrastructures, improving capacity to respond more quickly to outbreaks and considering multiple perspectives across disciplines during decision-making processes are among the key recommendations the authors propose.

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Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Fri, 2016-03-18 11:09 — davidmc

Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies (NAbs) targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.

(complet article)

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Two Ebola deaths and three suspected cases in Guinea 'flare-up'

Fri, 2016-03-18 10:50 — davidmc

World Health Organisation had just announced ‘milestone’ of no new infections in neighbouring Sierra Leone when latest fatalities came to light

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WHO statement on end of Ebola flare-up in Sierra Leone

Fri, 2016-03-18 10:33 — davidmc

WHO joins the government of Sierra Leone in marking the end of the recent flare-up of Ebola virus disease in the country. As of today, 17 March, 42 days have passed, two incubation cycles of the virus, since the last person confirmed to have Ebola virus disease in the country tested negative for a second time.

This latest flare-up of Ebola brings to 3 590 the number of lives lost in Sierra Leone to an epidemic that devastated families and communities across the country and disrupted every aspect of life.

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Treating Ebola with Plasma

Mon, 2016-03-14 14:06 — davidmc

During the Ebola outbreak of 1995 in the Democratic Republic of Congo, eight patients with Ebola were given blood transfusions from people who had recently recovered from Ebola. Seven of them survived.

The blood of people who have recently recovered from an infection contains antibodies that the body develops naturally to fight that infection. The transfusion of these antibodies into infected individuals (as whole blood, plasma, or concentrated antibodies) has a long history and has been proposed as a possible treatment for Ebola virus disease.

see more at: http://www.dddmag.com/news/2016/03/treating-ebola-plasma

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Building A More Resilient West Africa - How Open Innovation Can Help

Sat, 2016-02-27 20:29 — Kathy Gilbeaux

Improving local health workers’ access to real-time health information will enable a faster and better response to global health threats. / Neil Brandvold, USAID

medium.com/usaid-2030 - by Ann Mei Chang - February 11, 2016

. . . The next generation of health information systems have to not only quickly and accurately deliver the necessary information to healthcare workers, but they need to be able to communicate with each other. The wide range of people involved in combating epidemics such as Ebola need to be able to efficiently and seamlessly share information to ensure coordinated responses and better resource distribution. . . .

. . . To get the conversation started, USAID put out a call for innovative concepts for improving interoperability within health information systems in the developing world. We gathered over 40 organizations for a three-day co-creation workshop in Washington, D.C. in November. Almost 100 experts — including donors, engineers, software developers and implementers in the field — arrived to co-design a solution. . . .

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At Davos, U.N. Appeals For Final $1 Billion To Fight Ebola

Sat, 2016-01-23 05:41 — Kathy Gilbeaux

Fabrice Coffrini via Getty Images

huffingtonpost.com - by Ben Hirschler

DAVOS, Switzerland, Jan 21 (Reuters) - United Nations agencies need a final $1 billion to fight West Africa's deadly Ebola epidemic as experts move to a new phase involving a massive detective operation to trace remaining cases, the U.N. Ebola chief said on Wednesday.

David Nabarro estimated that an overall total of $4 billion in new money, equivalent to all the aid committed so far, was needed by relief agencies and the worst affected countries themselves to end the epidemic and "help these countries to get back to the economic trajectory they had."

(READ COMPLETE ARTICLE)

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This is How We Got to Zero Ebola Cases in West Africa:

Mon, 2016-01-04 14:45 — Kathy Gilbeaux

whitehouse.gov - by Amy Pope - December 30, 2015

Summary: The world has now gone over 40 consecutive days without a single reported Ebola case. Here's how we helped make that possible.

For the first time since this outbreak was detected in West Africa in early 2014, the world has now gone over 40 consecutive days without a single reported Ebola case.

The World Health Organization (WHO) announced that Guinea has successfully halted Ebola transmission and now joins Sierra Leone and Liberia in recovering from this devastating disease. This represents a significant milestone for Guinea, West Africa, and the international community.

Today we reflect on what is possible when partners around the world come together to solve a common problem. Through the undaunted courage of local communities and heroes from around the world, West Africa was able to halt Ebola. The United States was proud to offer help along with partners around the world.

Today we remember Ebola’s victims, and embrace the communities, families, healthcare workers, and survivors.

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CLICK HERE - A giant fullerene system inhibits the infection by an artificial Ebola virus

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A New Weapon in Fight Against Ebola

Sat, 2015-12-26 02:27 — Kathy Gilbeaux

The team has achieved an unprecedented goal: connecting 12 fullerenes, each one endowed with 10 sugar moieties, to other central fullerene, thus mimicking the presentation of carbohydrates surrounding the Ebola virus. Credit: N. Martín & B. Illescas / UCM

CLICK HERE - STUDY - Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

scitechconnect.elsevier.com - by SPLICE - November 19, 2015

A discovery which may lead to the elimination of Ebola infections was published in Nature Chemistry a few days ago. The investigators reported that giant fullerene system inhibits the cell infection by an artificial Ebola virus.

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