Africa

PLOS MEDICINE   by Ben Cooper and others                                                             April 14, 2015
Experimental treatments for Ebola virus disease might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic

A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT) with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT) without interim analyses.

Read complete study.

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001815

THE WORLD BANK                                                                           April 17, 2015

New GDP Estimates Show International Support Vital to Speed Recovery

WASHINGTON--The World Bank Group (WBG) announced today that it would provide at least US$650 million during the next 12 to 18 months to help Guinea, Liberia and Sierra Leone recover from the devastating social and economic impact of the Ebola crisis and advance their longer-term development needs. The new WBG pledge brings the organization’s total financing for Ebola response and recovery efforts to date to US$1.62 billion.

The additional funding announcement comes as the WBG releases new GDP estimates showing that the Ebola epidemic continues to cripple the economies of Guinea, Liberia and Sierra Leone. Estimated GDP losses for the three countries in 2015 rose to US$2.2 billion: US$240 million for Liberia, US$535 million for Guinea and US$1.4 billion for Sierra Leone. In addition to the severe effects of Ebola, the economic downturn in the three countries is aggravated by the sharp decline in global iron ore prices, as well as the collapse of the mining sector in Sierra Leone...

UNITED NATIONS NEWS CENTRE                                                      April 16, 2015

WASHINGTON  --Intense efforts to control the Ebola outbreak in the three most-affected West African countries in will continue, the United Nations health chief said in Washington, DC today, adding that the international community is also looking for ways to build on dramatic recent progress by aiding with efforts aimed at recovery from the outbreak.

Tuesday 14 April 2015 was a happy day in Sierra Leone as children returned to school after many months             away, due to the Ebola outbreak. Photo: WHO/N. Alexander

“The goal is to help people and their communities to return to a normal life again,” said Margaret Chan, Director-General of the World Health Organization (WHO). “It means that children are going back to school, women can once again shop in their local markets, and livelihoods are restored.”

 Cases may be nearing zero in certain areas, but the threat of the disease lingers

 TIME MAGAZINE  by Maya Rhodan                                                   April 16, 2015

There were only 37 confirmed cases of Ebola last week, just a year after the deadly virus was spreading quickly across Western Africa. But key stakeholders in the effort to reduce the number of cases to zero said Thursday that success is not guaranteed.

President Barack Obama, flanked by Liberian President Ellen Johnson Sirleaf, left, and Guinean President Alpha Condé, speaks in the Cabinet Room of the White House in Washington, Wednesday, April 15, 2015, to discuss the progress made in the international Ebola response. Manuel Balce Ceneta—AP

“We are dealing now with the most difficult areas,” said Bruce Aylward, the assistant director-general of polio and emergencies at the World Health Organization. “We’re dealing with issues of fear, of trust with communities that have been marginalized. That have not been fully engaged.”