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Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies (NAbs) targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.

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Two Ebola deaths and three suspected cases in Guinea 'flare-up'

World Health Organisation had just announced ‘milestone’ of no new infections in neighbouring Sierra Leone when latest fatalities came to light

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WHO statement on end of Ebola flare-up in Sierra Leone

WHO joins the government of Sierra Leone in marking the end of the recent flare-up of Ebola virus disease in the country. As of today, 17 March, 42 days have passed, two incubation cycles of the virus, since the last person confirmed to have Ebola virus disease in the country tested negative for a second time.

This latest flare-up of Ebola brings to 3 590 the number of lives lost in Sierra Leone to an epidemic that devastated families and communities across the country and disrupted every aspect of life.

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Treating Ebola with Plasma

During the Ebola outbreak of 1995 in the Democratic Republic of Congo, eight patients with Ebola were given blood transfusions from people who had recently recovered from Ebola. Seven of them survived.

The blood of people who have recently recovered from an infection contains antibodies that the body develops naturally to fight that infection. The transfusion of these antibodies into infected individuals (as whole blood, plasma, or concentrated antibodies) has a long history and has been proposed as a possible treatment for Ebola virus disease.

see more at: http://www.dddmag.com/news/2016/03/treating-ebola-plasma

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This is How We Got to Zero Ebola Cases in West Africa:

whitehouse.gov - by Amy Pope - December 30, 2015

Summary: The world has now gone over 40 consecutive days without a single reported Ebola case. Here's how we helped make that possible.

For the first time since this outbreak was detected in West Africa in early 2014, the world has now gone over 40 consecutive days without a single reported Ebola case.

The World Health Organization (WHO) announced that Guinea has successfully halted Ebola transmission and now joins Sierra Leone and Liberia in recovering from this devastating disease. This represents a significant milestone for Guinea, West Africa, and the international community.

Today we reflect on what is possible when partners around the world come together to solve a common problem. Through the undaunted courage of local communities and heroes from around the world, West Africa was able to halt Ebola. The United States was proud to offer help along with partners around the world.

Today we remember Ebola’s victims, and embrace the communities, families, healthcare workers, and survivors.

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Ebola outbreak in West Africa 22 months on: Key issues for recovery and preparedness, October 2015

                                                                     

acaps.org

Ebola Project, Thematic Report: Key issues for recovery and preparedness, Oct 2015 (3 page .PDF file)
http://acaps.org/img/documents/e-acaps-ebola-project-thematic-report-key-issues-for-recovery-and-preparedness-oct-2015.pdf

ACAPS - Thematic Reports
http://acaps.org/en/pages/ebola-project-sep-dec-2015-thematic-reports

 

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USAID Pumps US$290K in Recovery Plan for Ebola Survivors

submitted by Gavin Macgregor-Skinner

           

SFCG’s Director Bloh (L) and participants of the workshop (R)

liberianobserver.com - by Joaquin Sendolo - August 31, 2015

The United States Agency for International Development (USAID) has provided US$290,000 through IREX to Search for Common Ground (SFCG) to sensitize communities on the negative impacts stigma makes on Ebola survivors.

Since the outbreak of the Ebola virus disease (EVD) in Liberia, those who survived the disease have reportedly suffered stigma in various communities, thus causing them to feel discriminated against.

The stigma comes about because of fear that survivors could still be transmit[ting] the virus when they are touched since it is one way of contracting EVD.

(READ COMPLETE ARTICLE)

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Sierra Leone releases its last Ebola patient, to start countdown to WHO Ebola-free declaration

ASSOCIATED PRESS by CLARENCE ROY-MACAULAY    Aug. 24, 2015

MATENEH, Sierra Leone  — Health authorities in Sierra Leone released the country's last known Ebola patient from a hospital on Monday, a milestone that allows the nation to begin a 42-day countdown to being declared free of the virus that has killed nearly 4,000 people here.

Adama Sankoh, 40, centre, who contracted Ebola after her son died from the disease late last month stands with health officials the moment after she was discharge from Mateneh Ebola treatment center outskirt of Freetown, Sierra Leone, Monday, Aug. 24, 2015, Health authorities in Sierra Leone released the country's last known Ebola patient from the hospital on Monday, a milestone that allows the nation to begin a 42-day countdown to being declared free of the virus that has killed nearly 4,000 people here. (AP Photo/Alie Turay)

President Ernest Bai Koroma presented a certificate of discharge to Adama Sankoh, 40, who contracted Ebola after her son died from the disease late last month.

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Sierra Leone celebrates lifting of ban on public gatherings due to Ebola

THE GUARDIAN by Lisa O'Carroll                      Aug. 10, 2015

FREETOWN --Celebrations broke out all over Sierra Leone at the weekend after a ban on public gatherings prompted by the outbreak of Ebola more than a year ago was lifted.

                       People play football on a beach in Freetown. Photograph: Lisa O'Carroll for the Guardian

Sierra Leoneans were allowed to go to sporting events and nightclubs, and stay out in restaurants after 9pm, following the decision by the president, Ernest Bai Koroma, to lift the ban on Friday. Some partied hard into the night, while others played football on the beaches and flocked to makeshift cinemas to watch the Manchester United and Arsenal matches....

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RECORDED VIDEO - Ebola Innovation for Impact 2015 - Game Change in Global Health Crisis Management

Side Event in Support of the UN Secretary-General’s International Ebola Recovery Conference July 9-10 2015

United Nations Headquarters - Conference Room 3, 13.15-14.30 pm (1:15pm-2:30pm, ET), 10 July 2015

As a side-event in support of the United Nations Secretary-General’s International Ebola Recovery Conference, Ebola Innovation for Impact 2015: Game Change in Global Health Crisis Management will bring together thought leaders in global health and technology to stimulate creative, collaborative and catalytic action, and to address the Ebola crisis with innovative solutions in the key, inter-linked areas of: Community Engagement and Mobilization; Private Sector Contribution and Collaboration; Data Systems Strengthening and Coordination; and, Emergency Infrastructure and Logistics.

Speakers include:

Dr. Barbara Bentein, UNICEF

Dr. Arnaud Bernaert, World Economic Forum (WEF)

Dr. Vinton G. Cerf, Google

Dr. Denis Gilhooly, Global Digital Health Initiative (GDHI)

Dr. Michael D. McDonald, Global Health Response & Resilience Alliance (GHRRA)

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