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WHO Ebola Situation Report - 25 March 2015

WHO  WEEKLY SITUATION REPORT                                         March 25, 2015

Summary 

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Exposure Concerns Grow in Liberia After Diagnosis of First Ebola Case in Weeks

NEW YORK TIMES  by Sheri Fink                                                            March  25, 2015

Worries have widened in recent days over the number of people in Liberia who may have been exposed to the country’s first Ebola case in more than two weeks, a street vendor who lived in a one-bathroom house shared with 52 others in a Monrovia suburb and who had sold food at a school where more than 1,900 students are enrolled.

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New Ebola trial vaccine 'safe': researchers

AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

 But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

Read complete story.
http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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A Chemical Within a Traditional Chinese Medicine Has been Found to Be Effective Against Ebola

      

Health workers in protective clothing speak with new arrivals in the outpatient waiting room of Redemption Hospital, formerly an Ebola holding centre, in Liberia.  John Moore/Getty Images

CLICK HERE - SCIENCE - REPORT - Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

businessinsider.com.au - by Chris Pash - February 27, 2015

A chemical found in the Chinese herb known as Han Fang ji switches off the channels which the Ebola virus uses to enter and infect cells, according to research by US and German scientists.

The scientists found that using a small dose of the chemical tetrandrine, but not the herb itself, stopped the virus from replicating and protected mice from the disease without obvious side effects.

The discovery of the promising drug therapy against Ebola is announced in the journal Science.

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Sex the Hidden Culprit: A New Dimension in Ebola Infections in Liberia

africansuntimes.com - by Mardia Stone, M.D. - March 23, 2015

On March 20th, a newly confirmed Ebola case was reported [in Liberia] . . . This time, sexual contact is presumed to be the hidden culprit in this new Ebola virus transmission, according to a statement from the Ministry of Information and case reports from the National Ebola Response Team.

The story goes like this. . . .

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(ALSO SEE RELATED INFORMATION HERE)

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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The Ebola detectives

The BBC   by Hans Rosling                                                                    March 23, 2015
Interview with Swedish statistician and global health professor Hans Rosling who spent three months working as an epidemiologist in the Liberian Health Ministry helping to tackle the Ebola crisis.

 

                  Hans Rosling flanked by Maj Morris Hunh (China), to his right, and Gen Gary Volesky(U.S.) to his left

Excerpt from BBC interview:

The curve turned around because enough Ebola treatment units were built. Medecins Sans Frontieres ran the biggest. When that was not enough, Liberian doctors and nurses added the next treatment unit. But the race against time in September to provide treatment and isolation for all patients, when the epidemic curve climbed to 30, 40 and 50 patients per day, was won by the WHO.

 By the end of September, Dr Atai from Uganda opened the so-called Island Clinic which meant beds could be offered to all Ebola patients.The curve was curbed for four reasons:

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Ebola Diaries: Hitting the Ground Running

INFECTION CONTROL TODAY                                      March 24, 2015
The World Health Organization (WHO) is publishing a series, "Ebola Diaries," with first-person accounts of WHO staff and others deployed to the field for Ebola response since the first cases were reported in West Africa on March 23, 2014.
 
Dr. Stéphane Hugonnet, team lead for gobal capacities, alert and responses for the World Health Organization (WHO), was one of the first WHO experts sent to Guinea to investigate cases of Ebola reported in late March 2014. A medical doctor who has spent the past 20 years working for WHO, MSF and others, managing outbreaks ranging from cholera, measles and yellow fever, to Lassa, Ebola and meningitis, Hugonnet found a very different sort of outbreak when he arrived in Guinea.

"We were following this rumor of a small cluster of unexplained deaths in Guinea," he says. "Some thought it could be Lassa    phane fever, but the transmission pattern was very compatible with Ebola. When the lab results came back, we learned that there was Ebola Zaire in West Africa.            

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The hunters breaking an Ebola ban on bushmeat

BBC News by Mark Doyle                                                            March 23, 2015

Kabala, Sierra Leone- Scientists believe bushmeat is the origin of the current Ebola outbreak. A year ago, Sierra Leone put a ban on bushmeat - but is it working?
                         Bats are known carriers of the Ebola virus - this hunter was pictured last year

I linked up with a group of traditional hunters who were demonstrating how the Ebola-inspired ban on bushmeat hunting in Sierra Leone isn't working.

The ban came into force last year.

The Minister for Agriculture, Joseph Sam Sesay, confirmed to me that the ban was still in place and said it was broadly working.

But in the Wara Wara mountain range, the bushmeat hunters I met were obviously active.

Read complete story.
http://www.bbc.com/news/world-africa-31985826

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