Ebola: Overview of current state of vaccine development

Current state of Ebola virus vaccines: A snapshot plospathogens

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Thirteen EBOV vaccine candidates have entered human clinical trials with 5 progressing to post-Phase I clinical trials [8]. Strengths and weaknesses for each of the 5 platforms are summarized in Table 1. The most advanced vaccines in the United States and Europe include Ervebo (rVSV-EBOV), Zabdeno/Mvabea (Ad26-ZEBOV/MVA-BN-Filo), and cAd3-EBOZ (Fig 1). All 3 platforms use a viral vector, or a modified version of a harmless surrogate virus, to provoke an immune response. ...